Significance Of The Discovery Of Clodronate Liposome

By Roxanne Cruz


Perhaps medical science is the best industry in science because of the it made possible the inventions and discoveries that was once only imagined. Different solutions were found to cure different diseases acquired from viruses and bacteria. For example, thousands of residents died because yellow fever has got no medicine. But overtime, because of these hard working discoverers, vaccine for the fever was invented. Clodronate liposome is surely one of discoveries that is going to play a significant role in medicine industry.

Clodronate disodium or clodronic acid, or known commonly as clodronate is the first generation of bisphosphonate without nitrogen. It is a medicine and is approved to be used for the prevention and treatment of osteoporosis cases to women who are at their post menopausal stage. It is also said to deplete macrophages.

Macrophages are white blood cells inside tissues. They are produced through division of monocytes, a type of white blood cell which was formed in the bone marrow and spleen which ingests particles of cell and huge foreign particles. So basically macrophage is the center of immune system. It defends the body from any invasion of different kinds of parasites and foreign transplant.

Liposomes are the microscopic bubbles which are consist of fatty liquids. These are used in cell biology to study the cell and find cures to any diseases found in the cell. They are drugs that are used to help treat and cure cancer. But it does not only limit to cancer, scientists also approved that these drugs can be used in curing other diseases. It is made of liquid and phospholipids.

Clodronate liposome is a discovery which functions to suppress the macrophage. It is true that immune system fights bacteria and viruses. Through various steps so called the immune response, the system attacks these infectious invaders that may cause disease. But at the same time, this system could also be a culprit in the human body.

In most circumstances, the immune system helps the body cope up diseases like fever and colds. However, when it is damaged, it will attack all the cells including the healthy ones. With a stroke of misfortune, several grave disorders will take place.

Immune response does protect the body from invasion of the infectious organisms. But damages will also happen in the body when the transplant was rejected leading to the autoimmune condition. Transplant rejection is the side effect of the immune response. When a new organ is placed on the patient, cells will automatically work against forcefully to the organ cells. It will soon result to transplant rejection.

Medical people discovered a certain drug that will treat and cure cases like those. This is made of bisphosphonate the will lessen macrophage. It will be transplanted to the organ cell and as soon as it detected that it is foreign, it will automatically cover the whole transplant up and try to eat them through the so called phagocytosis.

Clodronate liposome also helps to improve anti tumor effects caused by anti tumor drugs during cancer. This may not be able to cure the disease but somehow it will increase plasma absorption. Though this discovery is of great significance in the medical science, before actually resorting in taking it, consult you doctor first.




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